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Revista de Medicina de Laboratorio 00222 / http://dx.doi.org/10.20960/revmedlab.00222

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Gammapatías monoclonales y otros trastornos de células plasmáticas: el rol emergente de la espectrometría de masas

Gema García-de la Rosa, Silvia de las Heras-Flórez, Mercedes Carretero-Pérez, Jorge Nuevo-García

Prepublicado: 2024-11-27

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Las gammapatías monoclonales y otros trastornos de células plasmáticas son enfermedades que involucran la proliferación anormal de células plasmáticas y la producción de inmunoglobulinas clonales. Históricamente, el diagnóstico y seguimiento de estas condiciones han dependido de técnicas como la electroforesis de proteínas y la inmunofijación, que identifican y caracterizan las proteínas monoclonales generadas por estas células. En los últimos años, la espectrometría de masas se ha posicionado como una tecnología clave en este campo. Esta herramienta avanzada ofrece una capacidad sin precedentes para detectar, identificar, cuantificar e isotipar proteínas monoclonales de manera precisa y temprana con una mayor sensibilidad y especificidad. Esto no solo mejora el diagnóstico inicial, sino que también facilita una monitorización continua y más efectiva de la progresión de la enfermedad.

Palabras Clave: Gammapatías monoclonales. Macroglobulinemia de Waldenström. amiloidosis de cadenas ligeras. Proteína monoclonal. Espectrometría de masas.

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