Revista de Medicina de Laboratorio 00022 / http://dx.doi.org/10.20960/revmedlab.00022

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Revisiones - Metaanálisis

El papel de los ritmos biológicos en la interpretación de los resultados en el laboratorio clínico. Conceptos básicos

María-Carmen Lorenzo-Lozano, Alfonso-Luis Blázquez-Manzanera, María Elena Redín Sarasola, Enrique Prada de Medio, Raquel Blázquez Sánchez, Laura Criado Gómez, Félix Gascón Luna, Daniel Pineda Tenor, Ana Cosmen Sánchez, Santiago Prieto Menchero

Prepublicado: 2020-09-30

Publicado: 2020-10-01

VOLUMEN 1, NÚM. 2, mayo-agosto (2020), PAG. 69-75

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La Cronobiología es la rama de la biología que estudia la organización temporal de los procesos fisiológicos. Aunque sus aplicaciones son ampliamente estudiadas en otras áreas de la medicina, en el laboratorio clínico existen nuevas oportunidades de investigación con la incorporación de la inteligencia artificial. Estamos familiarizados a asociar resultados de algunas hormonas a sus horas de extracción (cortisol o melatonina). Sin embargo, son pocos los estudios que analizan la presencia de variabilidad circadiana de otros parámetros analizados en el laboratorio clínico. Una correcta recogida de la hora de extracción de muestras por parte de los sistemas informáticos del laboratorio podría aportar información relevante para llevar a cabo estudios de investigación e interpretación en esta disciplina. Queremos presentar unas nociones básicas sobre Cronobiología e invitar al desarrollo de líneas de investigación en este campo.

Palabras Clave: Cronobiología. Ritmo biológico. Innovación en laboratorio clínico.

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de Mairan, J. D. (1729). Observation botanique. Histoire de l'Académie Royale des Sciences Paris.

Landois, L. (1885). d. Physiol. d. M. 1900. Realencycl. Bd, 163.

Canon, W. B. (1932). The wisdom of the body.
DOI: 10.1097/00000441-193212000-00028

Aschoff, J. (1960, January). Exogenous and endogenous components in circadian rhythms. In Cold Spring Harbor symposia on quantitative biology (Vol. 25, pp. 11-28). Cold Spring Harbor Laboratory Press
DOI: 10.1101/SQB.1960.025.01.004

Aschoff, J. (1979). Circadian Rhythms: Influences of Internal and External Factors on the Period Measured in Constant Conditions 1. Zeitschrift für Tierpsychologie, 49(3), 225-249
DOI: 10.1111/j.1439-0310.1979.tb00290.x

Aschoff, J., Daan, S., Figala, J., & Müller, K. (1972). Precision of entrained circadian activity rhythms under natural photoperiodic conditions. Naturwissenschaften, 59(6), 276-277.
DOI: 10.1007/BF00610214

Bunning, E. (1935). Zur Kenntnis der erblichen Tagesperiodizitat bei den Primarblattern von Phaseolus multiŻorus. Jahrb. Wiss. Botan, 81, 411ą418

Bunning, E. (1930). Uber die tagesperiodischen Bewegungen der Primarblatter von Phaseolus multiflorus. II. Die Bewegungen beim Thermokonstanz. Ber Deut Bot Ges, 48, 227-252

Pittendrigh, C. S., & Daan, S. (1976). A functional analysis of circadian pacemakers in nocturnal rodents. Journal of comparative physiology, 106(3), 223-252.
DOI: 10.1007/BF01417856

Pittendrigh, C. S. (1954). On temperature independence in the clock system controlling emergence time in Drosophila. Proceedings of the National Academy of Sciences, 40(10), 1018-1029.
DOI: 10.1073/pnas.40.10.1018

Sancar A, Lindsey-Boltz LA, Gaddameedhi S, Selby CP, Ye R, Chiou YY, Kemp MG, Hu J, Lee JH, Ozturk N. (2014). Circadian clock, cáncer and chemotherapy. Biochemistry. 54(2):110-23

Erren, T. C., & Reiter, R. J. (2009). Defining chronodisruption. Journal of pineal research, 46(3), 245-247
DOI: 10.1111/j.1600-079X.2009.00665.x

Young, M. W. (2018). Time Travels: A 40‐Year Journey from Drosophila's Clock Mutants to Human Circadian Disorders (Nobel Lecture). Angewandte Chemie International Edition, 57(36), 11532-11539
DOI: 10.1002/anie.201803337

Martinez-Nicolas, A., Madrid, J. A., & Rol, M. A. (2014). Day–night contrast as source of health for the human circadian system. Chronobiology international, 31(3), 382-393.
DOI: 10.3109/07420528.2013.861845

Moore, R. Y., Speh, J. C., & Leak, R. K. (2002). Suprachiasmatic nucleus organization. Cell and tissue research, 309(1), 89-98.
DOI: 10.1007/s00441-002-0575-2

Terzibasi-Tozzini, E., Martinez-Nicolas, A., & Lucas-Sánchez, A. (2017, October). The clock is ticking. Ageing of the circadian system: From physiology to cell cycle. In Seminars in cell & developmental biology (Vol. 70, pp. 164-176). Academic Press.
DOI: 10.1016/j.semcdb.2017.06.011

Ko, C. H., Yamada, Y. R., Welsh, D. K., Buhr, E. D., Liu, A. C., Zhang, E. E., & Takahashi, J. S. (2010). Emergence of noise-induced oscillations in the central circadian pacemaker. PLoS biology, 8(10), e1000513.
DOI: 10.1371/journal.pbio.1000513

Ruby, N. F., Brennan, T. J., Xie, X., Cao, V., Franken, P., Heller, H. C., & O'hara, B. F. (2002). Role of melanopsin in circadian responses to light. Science, 298(5601), 2211-2213.

Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., & Yau, K. W. (2003). Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in mice. Nature, 424(6944), 75.
DOI: 10.1038/nature01761

Peirson, S. N., & Foster, R. G. (2010). Nonimage Forming Photoreceptors. In The Circadian Clock (pp. 105-113). Springer, New York, NY.
DOI: 10.1007/978-1-4419-1262-6_4

Roenneberg, T., & Merrow, M. (1998). Molecular circadian oscillators: an alternative hypothesis. Journal of biological rhythms, 13(2), 167-179.
DOI: 10.1177/074873098129000011

Webb, A. B., Angelo, N., Huettner, J. E., & Herzog, E. D. (2009). Intrinsic, nondeterministic circadian rhythm generation in identified mammalian neurons. Proceedings of the National Academy of Sciences, 106(38), 16493-16498.
DOI: 10.1073/pnas.0902768106

Vanselow JT, Kramer A (2010) Posttranslational regulation of circadian clocks, In: U Albrecht (Ed.), Protein Reviews. Volume 12. The Circadian Clock, Springer Science, New York, pp. 79-104.

Van Someren, E. J., & Nagtegaal, E. (2007). Improving melatonin circadian phase estimates. Sleep medicine, 8(6), 590-601.
DOI: 10.1016/j.sleep.2007.03.012

Morgenthaler, T. I., Lee-Chiong, T., Alessi, C., Friedman, L., Aurora, R. N., Boehlecke, B., ... & Owens, J. (2007). Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. Sleep, 30(11), 1445-1459.
DOI: 10.1093/sleep/30.11.1445

Bonmati-Carrion, M. A., Arguelles-Prieto, R., Martinez-Madrid, M. J., Reiter, R., Hardeland, R., Rol, M. A., & Madrid, J. A. (2014). Protecting the melatonin rhythm through circadian healthy light exposure. International journal of molecular sciences, 15(12), 23448-23500.
DOI: 10.3390/ijms151223448

Erren, T. C., & Reiter, R. J. (2013). Revisiting chronodisruption: when the physiological nexus between internal and external times splits in humans. Naturwissenschaften, 100(4), 291-298.
DOI: 10.1007/s00114-013-1026-5

Martínez Nicolás, A. (2014). Interrelación entre los sincronizadores y el sistema circadiano humano= Crosstalk between synchronizers and the human circadian system. Proyecto de investigación,Tesis doctoral. Pittendrigh, C. S. (1981). Circadian systems: entrainment. In Biological rhythms (pp. 95-124). Springer, Boston, MA.

Pittendrigh, C. S. (1960, January). Circadian rhythms and the circadian organization of living systems. In Cold Spring Harbor symposia on quantitative biology (Vol. 25, pp. 159-184). Cold Spring Harbor Laboratory Press.
DOI: 10.1101/SQB.1960.025.01.015

Simonneaux, V., Garidou, M. L., Ribelayga, C., & Pévet, P. (2006). Mechanisms Underlying Seasonal Regulation of Melatonin Synthesis in Rodents. Melatonin: Biological Basis of Its, 1.

Refinetti, R., Cornélissen, G., & Halberg, F. (2007). Procedures for numerical analysis of circadian rhythms. Biological rhythm research, 38(4), 275-325.
DOI: 10.1080/09291010600903692

Witting, W., Kwa, I. H., Eikelenboom, P., Mirmiran, M., & Swaab, D. F. (1990). Alterations in the circadian rest-activity rhythm in aging and Alzheimer's disease. Biological psychiatry, 27(6), 563-572.
DOI: 10.1016/0006-3223(90)90523-5

Van Someren, E. J., Swaab, D. F., Colenda, C. C., Cohen, W., McCall, W. V., & Rosenquist, P. B. (1999). Bright light therapy: improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods. Chronobiology international, 16(4), 505-518.
DOI: 10.3109/07420529908998724

Martinez-Nicolas, A., Ortiz-Tudela, E., Madrid, J. A., & Rol, M. A. (2011). Crosstalk between environmental light and internal time in humans. Chronobiology international, 28(7), 617-629.
DOI: 10.3109/07420528.2011.593278

Lejeune-Lenain, C., Van Cauter, E., Désir, D., Beyloos, M., & Franckson, J. R. M. (1987). Control of circadian and episodic variations of adrenal androgens secretion in man. Journal of endocrinological investigation, 10(3), 267-276.
DOI: 10.1007/BF03348129

Van Coevorden, A., Laurent, E., Decoster, C., Kerkhofs, M., Neve, P., Van Cauter, E., & Mockel, J. (1989). Decreased basal and stimulated thyrotropin secretion in healthy elderly men. The Journal of Clinical Endocrinology & Metabolism, 69(1), 177-185.
DOI: 10.1210/jcem-69-1-177

Van Cauter, E., & Plat, L. (1996). Physiology of growth hormone secretion during sleep. The Journal of pediatrics, 128(5), S32-S37.
DOI: 10.1016/S0022-3476(96)70008-2

Van Cauter, E., L'Hermite, M., Copinschi, G., Refetoff, S., Desir, D., & Robyn, C. (1981). Quantitative analysis of spontaneous variations of plasma prolactin in normal man. American Journal of Physiology-Endocrinology And Metabolism, 241(5), E355-E363.
DOI: 10.1152/ajpendo.1981.241.5.E355

Haus, E., & Smolensky, M. H. (1999). Biologic rhythms in the immune system. Chronobiology international, 16(5), 581-622.
DOI: 10.3109/07420529908998730

Pritchett, D., & Reddy, A. B. (2015). Circadian clocks in the hematologic system. Journal of biological rhythms, 30(5), 374-388.
DOI: 10.1177/0748730415592729

Gumz, M. L. (2016). Taking into account circadian rhythm when conducting experiments on animals. American Journal of Physiology-Renal Physiology, 310(6), F454.
DOI: 10.1152/ajprenal.00549.2015

Panda, S. (2016). Circadian physiology of metabolism. Science, 354(6315), 1008-1015.

Blázquez, A.L., Lorenzo, M.C., Martos, A. L., González, E. D. R., Perea, M. P., Bullejos, P. F., ... & Martos, A. G. (2019). Circadian rhythm of glomerular filtration: A population-based descriptive study in two hospitals. Clinica Chimica Acta, 493, S480.

Lorenzo, M. C., Blázquez, A. L., Melguizo, D. M., González, D. R., Bullejos, P. F., Perea, M. P., ... & Martos, A. G. (2019). Correlation between population values of glomerular filtration and hematocrit circadian pattern of a regional hospital. Clinica Chimica Acta, 493, S487-S488.